Synthesis and cytotoxic activities of 4,5-diarylisoxazoles

  • Bioorg Med Chem Lett. 2007 Feb 15;17(4):1078-81. doi: 10.1016/j.bmcl.2006.11.023.
Chang-Ming Sun  1 ,  Lee-Gin Lin ,  Hsi-Jung Yu ,  Chih-Yu Cheng ,  Ya-Chuan Tsai ,  Chi-Wei Chu ,  Yi-Hui Din ,  Yat-Pang Chau ,  Ming-Jaw Don
Affiliations
  • 1. National Research Institute of Chinese Medicine, No. 155-1, Section 2, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC.
PMID: 17127061 DOI: 10.1016/j.bmcl.2006.11.023
Abstract

A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human Cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.