Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents

  • Bioorg Med Chem Lett. 2007 Feb 15;17(4):869-73. doi: 10.1016/j.bmcl.2006.11.060.
Maojiang Wu  1 ,  Qiming Sun ,  Chunhao Yang ,  Dongdong Chen ,  Jian Ding ,  Yi Chen ,  Liping Lin ,  Yuyuan Xie
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
PMID: 17174089 DOI: 10.1016/j.bmcl.2006.11.060
Abstract

A series of 4,5-disubstitute-1,2,3-thiadiazole compounds were designed and synthesized as potent Anticancer agents, some of them exhibited excellent in vitro and in vivo inhibitory activity.