Quinazoline and benzimidazole MCH-1R antagonists

  • Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. doi: 10.1016/j.bmcl.2006.11.092.
Rosa Arienzo  1 ,  Sue Cramp ,  Hazel J Dyke ,  Peter M Lockey ,  Dennis Norman ,  Alan G Roach ,  Phil Smith ,  Melanie Wong ,  Stephen P Wren
Affiliations
  • 1. Argenta Discovery Limited, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
PMID: 17178222 DOI: 10.1016/j.bmcl.2006.11.092
Abstract

We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.

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