Unusual naphthoquinone derivatives from the twigs of Avicennia marina

  • J Nat Prod. 2007 Jun;70(6):923-7. doi: 10.1021/np060587g.
Li Han  1 ,  Xueshi Huang ,  Hans-Martin Dahse ,  Ute Moellmann ,  Hongzheng Fu ,  Susanne Grabley ,  Isabel Sattler ,  Wenhan Lin
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
PMID: 17500572 DOI: 10.1021/np060587g
Abstract

In a continuing search for novel bioactive compounds from marine mangrove Plants, seven new naphthoquinone derivatives were isolated from Avicennia marina, namely, avicennone A (1), avicennone B (2), avicennone C (3), avicennone D (4), avicenone E (5), avicennone F (6), and avicennone G (7), along with the known compounds avicequinone A (8), stenocarpoquinone B (9), avicequinone C (10), avicenol A (11), and avicenol C (12). The chemical structures of 1-7 were elucidated by spectroscopic methods. Compounds 8-10, and a mixture of 4 and 5, which all contain a 4,9-dione group, showed strong antiproliferative and moderate cytotoxic activities, as well as Antibacterial effects.