Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring

  • Bioorg Med Chem Lett. 2007 Aug 1;17(15):4123-7. doi: 10.1016/j.bmcl.2007.05.050.
Mirjana Popsavin  1 ,  Sasa Spaić ,  Milos Svircev ,  Vesna Kojić ,  Gordana Bogdanović ,  Velimir Popsavin
Affiliations
  • 1. Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. [email protected]
PMID: 17543526 DOI: 10.1016/j.bmcl.2007.05.050
Abstract

This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-beta-dribofuranosyl)thiazole-4-carboxamide (2',3'-anhydro-tiazofurin) and the corresponding alpha- and beta-homo-C-nucleosides, as well as evaluation of their antitumour activities in vitro.