Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

  • Bioorg Med Chem Lett. 2007 Aug 15;17(16):4487-90. doi: 10.1016/j.bmcl.2007.06.007.
Mark C Manfredi  1 ,  Yingzhi Bi ,  Alexandra A Nirschl ,  James C Sutton ,  Ramakrishna Seethala ,  Rajasree Golla ,  Blake C Beehler ,  Paul G Sleph ,  Gary J Grover ,  Jacek Ostrowski ,  Lawrence G Hamann
Affiliations
  • 1. Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 17574413 DOI: 10.1016/j.bmcl.2007.06.007
Abstract

Replacement of the 3-oxo group of 2-chloro-4-[(7R,7aS)-7-hydroxy-1,3-dioxotetrahydro-1H-pyrrolo[1,2c]imidazol-2(3H)-yl]-3-methylbenzonitrile resulted in a sulfamide series of selective Androgen Receptor Modulator (SARM) agonists.