Aminopyrrolidineamide inhibitors of site-1 protease

  • Bioorg Med Chem Lett. 2007 Aug 15;17(16):4411-4. doi: 10.1016/j.bmcl.2007.06.031.
Bruce A Hay  1 ,  Barbara Abrams ,  Allice Y Zumbrunn ,  James J Valentine ,  Laurie C Warren ,  Stephen F Petras ,  Lorraine D Shelly ,  Angela Xia ,  Alison H Varghese ,  Julie L Hawkins ,  Jennifer A Van Camp ,  Michael D Robbins ,  Katherine Landschulz ,  H James Harwood Jr
Affiliations
  • 1. Pfizer Global Research and Development-Groton Laboratories, Groton, CT 06340, USA. [email protected]
PMID: 17583500 DOI: 10.1016/j.bmcl.2007.06.031
Abstract

The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.