Cytotoxic staurosporines from the marine ascidian Cystodytes solitus

  • J Nat Prod. 2008 Jun;71(6):1046-8. doi: 10.1021/np700748h.
Fernando Reyes  1 ,  Rogelio Fernández ,  Alfredo Rodríguez ,  Santiago Bueno ,  Carlos de Eguilior ,  Andrés Francesch ,  Carmen Cuevas
Affiliations
  • 1. Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain. [email protected].
PMID: 18484775 DOI: 10.1021/np700748h
Abstract

Two new indolocarbazole Alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines.