A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties

  • Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073.
Ingrid C Choong  1 ,  Iana Serafimova ,  Junfa Fan ,  David Stockett ,  Erica Chan ,  Sravanthi Cheeti ,  Yafan Lu ,  Bruce Fahr ,  Phuongly Pham ,  Michelle R Arkin ,  Duncan H Walker ,  Ute Hoch
Affiliations
  • 1. Medicinal Chemistry, Sunesis Pharmaceuticals, South San Francisco, CA 94080, USA. [email protected]
PMID: 18842409 DOI: 10.1016/j.bmcl.2008.09.073
Abstract

The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.