Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell

  • Chem Biol Drug Des. 2008 Oct;72(4):320-8. doi: 10.1111/j.1747-0285.2008.00703.x.
Laura Cascales  1 ,  Carlos Mas-Moruno ,  Silvia Tamborero ,  José Luis Aceña ,  Juan F Sanz-Cervera ,  Santos Fustero ,  Luis J Cruz ,  Puig Mora ,  Fernando Albericio ,  Enrique Pérez-Payá
Affiliations
  • 1. Department of Medicinal Chemistry, Centro de Investigaciones Principe Felipe, E-46013 Valencia, Spain.
PMID: 18844678 DOI: 10.1111/j.1747-0285.2008.00703.x
Abstract

The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially comprised the Prestwick Chemical library, as sources of Bacterial endotoxin neutralizers. We identified 3,3',5-triiodo-thyroacetic acid (tiratricol) as a non-antibacterial compound that neutralizes the toxic lipopolysaccharide.

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