Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida

  • Bioorg Med Chem Lett. 2009 Jan 1;19(1):77-9. doi: 10.1016/j.bmcl.2008.11.014.
Biswanath Das  1 ,  Kongara Ravinder Reddy ,  Bommena Ravikanth ,  Tuniki Venugopal Raju ,  Balasubramanian Sridhar ,  Patan Usman Khan ,  Janapala Venkateswara Rao
Affiliations
  • 1. Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India. [email protected]
PMID: 19036584 DOI: 10.1016/j.bmcl.2008.11.014
Abstract

Chemical examination of the stems of Jatropha multifida afforded a novel lathyrane-type diterpene, multifidone, having an unusual six-membered A ring. The structure of the compound was determined from detailed analysis of its 1D and 2D NMR spectra and X-ray crystallographic analysis. Its cytotoxicity was measured on four different cancerous cell lines.