Phenolic constituents from the stem bark of Magnolia officinalis

  • J Nat Prod. 2009 Jan;72(1):168-71. doi: 10.1021/np800494e.
Chien-Chang Shen  1 ,  Ching-Li Ni ,  Yuh-Chiang Shen ,  Yu-Ling Huang ,  Ching-Hsia Kuo ,  Tian-Shung Wu ,  Chien-Chih Chen
Affiliations
  • 1. National Research Institute of Chinese Medicine, Taipei, 112, Taiwan, Republic of China.
PMID: 19086868 DOI: 10.1021/np800494e
Abstract

Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2-8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4-7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.

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