Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia

  • Arch Pharm Res. 2008 Dec;31(12):1547-51. doi: 10.1007/s12272-001-2149-3.
Hong-Wen Tao  1 ,  Xiao-Jiang Hao ,  Pei-Pei Liu ,  Wei-Ming Zhu
Affiliations
  • 1. Key Laboratory of Marine Drugs, Ministry of Education, Qingdao, China.
PMID: 19099222 DOI: 10.1007/s12272-001-2149-3
Abstract

A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC(50) values of 2.7 and 9.0 microM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.

Products