Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

  • Bioorg Med Chem. 2009 Apr 1;17(7):2712-7. doi: 10.1016/j.bmc.2009.02.046.
Surya K De  1 ,  Li-Hsing Chen ,  John L Stebbins ,  Thomas Machleidt ,  Megan Riel-Mehan ,  Russell Dahl ,  Vida Chen ,  Hongbin Yuan ,  Elisa Barile ,  Aras Emdadi ,  Ria Murphy ,  Maurizio Pellecchia
Affiliations
  • 1. Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
PMID: 19282190 DOI: 10.1016/j.bmc.2009.02.046
Abstract

A new series of 2-thioether-benzothiazoles has been synthesized and evaluated for JNK inhibition. The SAR studies led to the discovery of potent, allosteric JNK inhibitors with selectivity against p38.