New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

  • Bioorg Med Chem Lett. 2009 May 1;19(9):2562-5. doi: 10.1016/j.bmcl.2009.03.045.
P Prabhakar Reddy  1 ,  Ashok K Tiwari ,  R Ranga Rao ,  K Madhusudhana ,  V Rama Subba Rao ,  Amtul Z Ali ,  K Suresh Babu ,  J Madhusudana Rao
Affiliations
  • 1. Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India.
PMID: 19332371 DOI: 10.1016/j.bmcl.2009.03.045
Abstract

Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.

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