Anti-coxsackie virus B3 norsesquiterpenoids from the roots of Phyllanthus emblica

  • J Nat Prod. 2009 May 22;72(5):969-72. doi: 10.1021/np800792d.
Qing Liu  1 ,  Ya-Feng Wang ,  Rong-Jie Chen ,  Mei-Ying Zhang ,  Yi-Fei Wang ,  Chong-Ren Yang ,  Ying-Jun Zhang
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 19374435 DOI: 10.1021/np800792d
Abstract

Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two Other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their Antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.