Cytotoxic triterpenoids from the stems of Microtropis japonica

  • J Nat Prod. 2009 Jul;72(7):1231-6. doi: 10.1021/np800694b.
I-Hsiao Chen  1 ,  Mei-Chin Lu ,  Ying-Chi Du ,  Ming-Hong Yen ,  Chin-Chung Wu ,  Yung-Husan Chen ,  Chih-Sheng Hung ,  Shu-Li Chen ,  Fang-Rong Chang ,  Yang-Chang Wu
Affiliations
  • 1. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
PMID: 19534471 DOI: 10.1021/np800694b
Abstract

Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.