The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce

  • Planta Med. 2010 Feb;76(2):185-9. doi: 10.1055/s-0029-1186047.
Fan Liu  1 ,  Xiao-Ling Cai ,  Hong Yang ,  Xue-Kui Xia ,  Zhi-Yong Guo ,  Jie Yuan ,  Meng-Feng Li ,  Zhi-Gang She ,  Yong-Cheng Lin
Affiliations
  • 1. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China.
PMID: 19670161 DOI: 10.1055/s-0029-1186047
Abstract

Bioactivity-directed fractionation of the extract of the mangrove endophytic fungus Talaromyces sp. ZH-154, which was isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae, afforded two new metabolites, 7-epiaustdiol ( 1) and 8-O-methylepiaustdiol ( 2), together with the known compounds, stemphyperylenol ( 3), skyrin ( 4), secalonic acid A ( 5), emodin ( 6), and norlichexanthone ( 7). Their structures were elucidated on the basis of spectroscopic evidences including CD, MS, and 1D, 2D NMR techniques. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction. All isolated compounds were evaluated for their antimicrobial and in vitro cytotoxic activities.

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