Sesquiterpenoids from Pilea cavaleriei subsp. crenata

  • Bioorg Med Chem Lett. 2009 Oct 1;19(19):5737-40. doi: 10.1016/j.bmcl.2009.08.001.
Gui-Hua Tang  1 ,  Chang-Song Sun ,  Chun-Lin Long ,  Ma-Lin Li ,  Yue-Hu Wang ,  Min Luo ,  Hong-Sheng Wang ,  Ya-Na Shi
Affiliations
  • 1. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
PMID: 19700322 DOI: 10.1016/j.bmcl.2009.08.001
Abstract

Three new humulane-type Sesquiterpenes, 8-O-(p-coumaroyl)-5beta-hydroperoxy-1(10)E,4(15)-humuladien-8alpha-ol (1), 8-O-(3-nitro-p-coumaroyl)-1(10)E,4(15)-humuladien-5beta,8alpha-diol (2) and 8-O-(p-coumaroyl)-1(10)E,4(5)E-humuladien-8-ol (3), and a new copaborneol derivative, 1-O-p-coumaroyl-copaborneol (4), have been isolated from the methanol extract of Pileacavaleriei Lévl. subsp. crenata C. J. Chen. Their structures were elucidated using spectroscopic methods. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated.