Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa

  • J Nat Prod. 2009 Sep;72(9):1686-90. doi: 10.1021/np900365r.
Kazumasa Zaima  1 ,  Tomoko Hirata ,  Takahiro Hosoya ,  Yusuke Hirasawa ,  Koichiro Koyama ,  Abdul Rahman ,  Idha Kusumawati ,  Noor Cholies Zaini ,  Motoo Shiro ,  Hiroshi Morita
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo, Japan.
PMID: 19711971 DOI: 10.1021/np900365r
Abstract

Two new bisindole Alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human Cancer cell lines.