Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

  • J Nat Prod. 2009 Sep;72(9):1585-8. doi: 10.1021/np900220r.
Hongbing Liu  1 ,  RuAngelie Edrada-Ebel ,  Rainer Ebel ,  Yao Wang ,  Barbara Schulz ,  Siegfried Draeger ,  Werner E G Müller ,  Victor Wray ,  Wenhan Lin ,  Peter Proksch
Affiliations
  • 1. Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany.
PMID: 19778087 DOI: 10.1021/np900220r
Abstract

Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine Sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC(50) against L5178Y cell line: 0.6 microg/mL).