Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds

  • J Med Chem. 1990 Nov;33(11):2976-81. doi: 10.1021/jm00173a012.
J Engel  1 ,  I Fleischhauer ,  V Jakovlev ,  A Kleemann ,  B Kutscher ,  B Nickel ,  H Rauer ,  U Werner ,  I Szelenyi ,  C E Johanson
Affiliations
  • 1. ASTA Pharma AG, Frankfurt, FRG.
PMID: 1977910 DOI: 10.1021/jm00173a012
Abstract

In the course of studies on tranquilizers, new non-benzodiazepine-like compounds were synthesized. These are 1-(3,4,5-trimethoxyphenoxy)-3-[4-(2-methoxyphenyl)piperazinyl]prop an-2-ol (INN: enciprazine) and derivatives thereof which were screened pharmacologically in order to evaluate their central nervous system activity. Compounds with marked antiaggressive and anxiolytic properties but without dependence potential could be detected. Enciprazine was selected for clinical investigations.

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