Total synthesis and biological evaluation of methylgerambullone

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):52-5. doi: 10.1016/j.bmcl.2009.11.040.
Jong Taik Moon  1 ,  Sung Hoon Ha ,  So Hyung Lee ,  Tae Hui Kwon ,  Chun Rim Oh ,  Young Deuk Kim ,  Jungahn Kim ,  Dong Joon Choo ,  Jae Yeol Lee
Affiliations
  • 1. Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea.
PMID: 19945876 DOI: 10.1016/j.bmcl.2009.11.040
Abstract

First total synthesis of methylgerambullone (MGB, 1) isolated from Glycosmis angustifolia was completed via a convergent route. The effect of MGB on the contractile responses of the isolated guinea-pig ileum induced by acetylcholine was investigated. As a result, it showed a potent relaxation rate (78.66+/-4.30% at 100mg/L) in a concentration-dependent manner on longitudinal smooth muscle contraction of isolated guinea-pig ileum induced by 1microM acetylcholine.

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