Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell

  • J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558.
Na Ri Kim  1 ,  Seung Kyu Kang ,  Hyun Hee Ahn ,  Sung Wook Kwon ,  Woul Seong Park ,  Ki Suk Kim ,  Sung Soo Kim ,  Hee Jung Jung ,  Sang Un Choi ,  Jin Hee Ahn ,  Kwang Rok Kim
Affiliations
  • 1. Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
PMID: 20014867 DOI: 10.1021/jm9015558
Abstract

A new synthetic small molecule, compound 1, which induced a neuronal differentiation from mesenchymal stem cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.

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