Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum

  • J Nat Prod. 2010 Jul 23;73(7):1250-3. doi: 10.1021/np1000939.
Mallika Kumarihamy  1 ,  Frank R Fronczek ,  Daneel Ferreira ,  Melissa Jacob ,  Shabana I Khan ,  N P Dhammika Nanayakkara
Affiliations
  • 1. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
PMID: 20550123 DOI: 10.1021/np1000939
Abstract

Four new 1,4-dihydroxy-5-phenyl-2-pyridinone Alkaloids (1-4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of these compounds were determined by spectroscopic methods, and the absolute configuration of the major compound (1) was determined by X-ray crystallographic analysis. Compound 1 exhibited moderate in vitro antiplasmodial (antimalarial) activity against chloroquine-sensitive (D6) and -resistant (W2) strains of Plasmodium falciparum and cytotoxic activity to Vero cells. Compound 2 was moderately active against both methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus.