Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

  • Eur J Med Chem. 2010 Sep;45(9):4403-8. doi: 10.1016/j.ejmech.2010.06.029.
Miguel A González  1 ,  Juan Mancebo-Aracil ,  Veronica Tangarife-Castaño ,  Lee Agudelo-Goméz ,  Bibiana Zapata ,  Ana Mesa-Arango ,  Liliana Betancur-Galvis
Affiliations
  • 1. Departamento de Química Orgánica, Universidad de Valencia, Dr Moliner 50, E-46100 Burjassot, Valencia, Spain. [email protected]
PMID: 20619938 DOI: 10.1016/j.ejmech.2010.06.029
Abstract

Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and Antiviral activities. Their precursors were similarly evaluated.