Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia

  • J Nat Prod. 2010 Sep 24;73(9):1563-7. doi: 10.1021/np100452a.
Peng-Cheng Wang  1 ,  Xin-Hui Ran ,  Rui Chen ,  Huai-Rong Luo ,  Yu-Qing Liu ,  Jun Zhou ,  You-Xing Zhao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 20812738 DOI: 10.1021/np100452a
Abstract

Eight new germacrane-type sesquiterpenoids, volvalerenals A-E (2-6) and volvalerenic acids A-C (7-9), along with four known compounds, were isolated from a chloroform extract of the roots of Valeriana officinalis var. latifolia. The structures and relative configurations of 2-9 were elucidated on the basis of spectroscopic data interpretation. The effects of all compounds isolated on acetylcholinesterase were evaluated.

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