Synthesis and antitumor activity of ureas containing pyrimidinyl group

  • Eur J Med Chem. 2011 Jan;46(1):429-32. doi: 10.1016/j.ejmech.2010.11.026.
Chuanfei Jin  1 ,  Yong-Ju Liang ,  Hongwu He ,  Liwu Fu
Affiliations
  • 1. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, PR China.
PMID: 21144621 DOI: 10.1016/j.ejmech.2010.11.026
Abstract

A novel series of ureas containing pyrimidinyl group were designed and synthesized. Some of the prepared compounds showed potential cytotoxicity against several human Cancer cell lines. From the structure-activity relationships we may conclude that introduction of a sulfide bridge between phenyl and pyrimidinyl rings would be critical for their biological activities.