FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor

  • Agents Actions. 1990 Jun;30(3-4):432-42. doi: 10.1007/BF01966309.
A Blackham  1 ,  R J Griffiths ,  C Hallam ,  J Mann ,  P D Mitchell ,  A A Norris ,  W T Simpson
Affiliations
  • 1. Department of Biochemistry, Fisons plc-Pharmaecutical Division, Loughborough, Leicestershire, UK.
PMID: 2117338 DOI: 10.1007/BF01966309
Abstract

FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activity in vivo in a number of models. It inhibited peritoneal inflammation induced by immune-complex when given locally. When applied to the skin, FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.

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