Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii

  • J Nat Prod. 2011 Jan 28;74(1):82-5. doi: 10.1021/np100358a.
Helen Sheridan  1 ,  Cora Nestor ,  Lorraine O'Driscoll ,  Ingrid Hook
Affiliations
  • 1. Natural Product Drug Discovery Group, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, 23 Westland Row, Dublin 2, Ireland. [email protected]
PMID: 21174407 DOI: 10.1021/np100358a
Abstract

Two new furanonaphthoquinones, (3R)-7-methoxy-α-dunnione (5) and (3R)-6-hydroxy-7-methoxy-α-dunnione (6), along with the known (3R)-dunnione (1), (3R)-α-dunnione (2), (3R)-7-hydroxy-α-dunnione (3), and 1-hydroxy-2-methylanthraquinone (4), were isolated from in vitro cultures of Streptocarpus dunnii. The structures of compounds 5 and 6 were established by spectroscopic means. This is the first report of hydroxylated furanonaphthoquinones in a Streptocarpus species. Compounds 1-3 demonstrated cytotoxic activity against a range of breast Cancer and pancreatic tumor cell lines.