Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

  • Bioorg Med Chem Lett. 2011 Apr 1;21(7):2075-8. doi: 10.1016/j.bmcl.2011.02.003.
Ki Hyun Kim  1 ,  Min Ah Kim ,  Eunjung Moon ,  Sun Yeou Kim ,  Sang Zin Choi ,  Mi Won Son ,  Kang Ro Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon, Gyeonggi-do 440-746, Republic of Korea.
PMID: 21353549 DOI: 10.1016/j.bmcl.2011.02.003
Abstract

The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D. japonica. Their structures were determined by spectroscopic methods, including 1D and 2D NMR techniques, HRMS, and chemical methods. Nerve growth factor (NGF), a crucial factor for neuronal survival and differentiation, can potentially improve neurodegenerative diseases and diabetic polyneuropathy. We evaluated the effects of isolates (1-12) on NGF induction in a C6 rat glioma cell line. Coreajaponin B (2) upregulated NGF content without significant cell toxicity, as did 6, 8, 9, and 11.

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