Chisomicines A-C, limonoids from Chisocheton ceramicus

  • J Nat Prod. 2011 May 27;74(5):1313-7. doi: 10.1021/np200013g.
Ibrahim A Najmuldeen  1 ,  A Hamid A Hadi ,  Khalijah Awang ,  Khalit Mohamad ,  Kamal Aziz Ketuly ,  Mat Ropi Mukhtar ,  Soon-Lim Chong ,  Gomathi Chan ,  Mohd Azlan Nafiah ,  Ng Seik Weng ,  Osamu Shirota ,  Takahiro Hosoya ,  Alfarius E Nugroho ,  Hiroshi Morita
Affiliations
  • 1. Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
PMID: 21428417 DOI: 10.1021/np200013g
Abstract

Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.