Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II

  • Bioorg Med Chem Lett. 2011 May 15;21(10):3117-21. doi: 10.1016/j.bmcl.2011.03.013.
Karem Shanab  1 ,  Eva Schirmer ,  Eva Wulz ,  Barbara Weissenbacher ,  Sigrid Lassnig ,  Rita Slanz ,  Germana Fösleitner ,  Wolfgang Holzer ,  Helmut Spreitzer ,  Peter Schmidt ,  Babette Aicher ,  Gilbert Müller ,  Eckhard Günther
Affiliations
  • 1. Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
PMID: 21458262 DOI: 10.1016/j.bmcl.2011.03.013
Abstract

A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.