Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326
- J Am Chem Soc. 2011 May 11;133(18):6865-7. doi: 10.1021/ja1110688.
Affiliations
- 1. Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.
PMID: 21500849
DOI: 10.1021/ja1110688
Abstract
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated Fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Endogenous MetaboliteResearch Areas: Infection