Structure and cytotoxicity of diterpenoids from Isodon adenolomus
- J Nat Prod. 2011 May 27;74(5):1213-20. doi: 10.1021/np200140j.
Affiliations
- 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 21534539
DOI: 10.1021/np200140j
Abstract
Twelve new Diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC50 values in the range 0.7-9.7 μM.
Products
-
Cat. No.Product NameDescriptionTargetResearch Area
-