Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala

  • J Nat Prod. 2011 May 27;74(5):1230-5. doi: 10.1021/np200164k.
Hanxiang Li  1 ,  Hongbo Huang ,  Changlun Shao ,  Huarong Huang ,  Jieyi Jiang ,  Xun Zhu ,  Yayue Liu ,  Lan Liu ,  Yongjun Lu ,  Mengfeng Li ,  Yongcheng Lin ,  Zhigang She
Affiliations
  • 1. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
PMID: 21545109 DOI: 10.1021/np200164k
Abstract

Four new norsesquiterpene peroxides, named talaperoxides A-D (1-4), as well as one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by 1D and 2D NMR. Structures of 1, 2, and 5 were further confirmed by single-crystal X-ray diffraction, and their absolute configurations were also determined using copper radiation. Cytotoxic activities of compounds 1-5 were evaluated in vitro against human Cancer cell lines MCF-7, MDA-MB-435, HepG2, HeLa, and PC-3. Compounds 2 and 4 showed cytotoxicity against the five human Cancer cell lines with IC50 values between 0.70 and 2.78 μg/mL.