Phenols with anti-HIV activity from Daphne acutiloba

  • Planta Med. 2012 Jan;78(2):182-5. doi: 10.1055/s-0031-1280263.
Sheng Zhuo Huang  1 ,  Xing Jie Zhang ,  Xing Yao Li ,  He Zhong Jiang ,  Qing Yun Ma ,  Peng Cheng Wang ,  Yu Qing Liu ,  Jiang Miao Hu ,  Yong Tang Zheng ,  Jun Zhou ,  You Xing Zhao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
PMID: 21989641 DOI: 10.1055/s-0031-1280263
Abstract

The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new Lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy aswell as HR‑ESI‑MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIVactivity with EC(50) values of 0.39 and 0.16 μg/mL, respectively.

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