Three new diterpenoids from the leaves of Thuja orientalis

  • Planta Med. 2012 Mar;78(5):485-7. doi: 10.1055/s-0031-1298215.
Chung Sub Kim  1 ,  Sang Un Choi ,  Kang Ro Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
PMID: 22294263 DOI: 10.1055/s-0031-1298215
Abstract

Three new Diterpenoids, 18-formyloxy-8 β-hydroxysandaracopimar-15-ene (1), 15(R)-N-butoxypinusolidic acid (2), and 15,16-dihydro-15,16-dimethoxylambertianic acid (3), along with twelve known compounds (4-15) were isolated from MeOH extracts of leaves of Thuja orientalis L. The structures of the three new compounds were elucidated on the basis of spectroscopic analyses, including extensive 2D-NMR data. The absolute stereochemistry of compound 2 was clarified by a CD spectroscopic study. The isolated compounds were evaluated for cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the sulforhodamin B (SRB) bioassay.

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