Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α

  • Biosci Biotechnol Biochem. 2012;76(4):847-9. doi: 10.1271/bbb.110908.
Hye-Sun Shin  1 ,  Seong-Il Kang ,  Seon-A Yoon ,  Hee-Chul Ko ,  Se-Jae Kim
Affiliations
  • 1. Department of Biology, Jeju National University, Jejusi, Jeju, Republic of Korea.
PMID: 22484952 DOI: 10.1271/bbb.110908
Abstract

Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

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