Synthesis and immunostimulating properties of novel adamant-1-yl tripeptides

  • Chem Biodivers. 2012 Apr;9(4):777-88. doi: 10.1002/cbdv.201100232.
Rosana Ribić  1 ,  Lidija Habjanec ,  Branka Vranešić ,  Ruža Frkanec ,  Srđanka Tomić
Affiliations
  • 1. Department of Chemistry, University of Zagreb, Zagreb, Croatia.
PMID: 22492495 DOI: 10.1002/cbdv.201100232
Abstract

The aim of this work was to prepare L- and D-(adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their Adjuvant (immunostimulating) activities. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH(2) )-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides.

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