Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs
- Biol Pharm Bull. 2012;35(8):1295-9. doi: 10.1248/bpb.b12-00145.
Affiliations
- 1. Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China.
PMID: 22863928
DOI: 10.1248/bpb.b12-00145
Abstract
We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their Anticancer activity in Cell Culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.
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