Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana

  • Bioorg Med Chem Lett. 2012 Oct 15;22(20):6377-80. doi: 10.1016/j.bmcl.2012.08.074.
Chang-Jiu Ji  1 ,  Guang-Zhi Zeng ,  Jing Han ,  Wen-Jun He ,  Yu-Mei Zhang ,  Ning-Hua Tan
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
PMID: 22989532 DOI: 10.1016/j.bmcl.2012.08.074
Abstract

Zizimauritic acids A-C (1-3), three novel nortriterpenes with a unique A-nor-E-seco spiro-lactone ceanothane-type triterpene skeleton, together with 3 known Triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1-4 showed cytotoxicities with the IC(50) values ranging from 5.05 to 11.94 μg/ml, and compounds 1 and 3 showed an inhibitory effect on the growth of Staphylococcus aureus with the IC(50) values 2.17 and 12.79 μg/ml. A plausible biosynthetic pathway of compounds 1-3 was proposed.