Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

  • Chem Commun (Camb). 2012 Nov 4;48(85):10508-10. doi: 10.1039/c2cc35721f.
Aude Colon  1 ,  Thomas J Hoffman ,  Julian Gebauer ,  Jyotirmayee Dash ,  James H Rigby ,  Stellios Arseniyadis ,  Janine Cossy
Affiliations
  • 1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
PMID: 22992661 DOI: 10.1039/c2cc35721f
Abstract

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial Antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

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