The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR

  • Molecules. 2012 Sep 27;17(10):11484-94. doi: 10.3390/molecules171011484.
Kang In Choe  1 ,  Joo Hee Kwon ,  Kwan Hee Park ,  Myeong Hwan Oh ,  Manh Heun Kim ,  Han Hyuk Kim ,  Su Hyun Cho ,  Eun Kyung Chung ,  Sung Yi Ha ,  Min Won Lee
Affiliations
  • 1. College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
PMID: 23018923 DOI: 10.3390/molecules171011484
Abstract

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4'-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.

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