Anti-inflammatory norditerpenoids from the soft coral Sinularia maxima

  • Bioorg Med Chem Lett. 2013 Jan 1;23(1):228-31. doi: 10.1016/j.bmcl.2012.10.129.
Nguyen Phuong Thao  1 ,  Nguyen Hoai Nam ,  Nguyen Xuan Cuong ,  Tran Hong Quang ,  Pham The Tung ,  Le Duc Dat ,  Doobyeong Chae ,  Sohyun Kim ,  Young-Sang Koh ,  Phan Van Kiem ,  Chau Van Minh ,  Young Ho Kim
Affiliations
  • 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam.
PMID: 23200246 DOI: 10.1016/j.bmcl.2012.10.129
Abstract

Chemical investigation of the soft coral Sinularia maxima resulted in the isolation of seven norditerpenoids, including two new compounds, 12-hydroxy-scabrolide A (2) and 13-epi-scabrolide C (6). The structures of the isolated compounds were elucidated based on extensive spectroscopic evidence including Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and both one- and two-dimensional nuclear magnetic resonance (1D and 2D NMR, respectively), in comparison with reported data. Compound 6 potently inhibited IL-12 and IL-6 production in LPS-stimulated bone marrow derived dendritic (BMDCs) with IC(50) values of 5.30 ± 0.21 and 13.12 ± 0.64 μM, respectively. Compound 1 exhibited moderate inhibitory activity against IL-12 and IL-6 production with IC(50) values of 23.52 ± 1.37 and 69.85 ± 4.11 μM, respectively.