Non-benzimidazole containing inhibitors of respiratory syncytial virus

  • Bioorg Med Chem Lett. 2013 Feb 1;23(3):827-33. doi: 10.1016/j.bmcl.2012.11.062.
David C Pryde  1 ,  Thien-Duc Tran ,  Iain Gardner ,  Helen Bright ,  Paul Stupple ,  Sebastien Galan ,  Liam Alsop ,  Lesa Watson ,  Donald S Middleton ,  Satish Dayal ,  Michelle Platts ,  Edward J Murray ,  Tanya Parkinson ,  Robert Webster
Affiliations
  • 1. Worldwide Medicinal Chemistry, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. [email protected]
PMID: 23265891 DOI: 10.1016/j.bmcl.2012.11.062
Abstract

Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of Antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.