Aaptamine derivatives from the Indonesian sponge Aaptos suberitoides

  • J Nat Prod. 2013 Jan 25;76(1):103-6. doi: 10.1021/np300794b.
Cong-Dat Pham  1 ,  Rudolf Hartmann ,  Werner E G Müller ,  Nicole de Voogd ,  Daowan Lai ,  Peter Proksch
Affiliations
  • 1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany.
PMID: 23282083 DOI: 10.1021/np300794b
Abstract

Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the Sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.