Anti-inflammatory diterpenoids from Croton tonkinensis

  • J Nat Prod. 2013 Feb 22;76(2):230-6. doi: 10.1021/np300699f.
Ping-Chung Kuo  1 ,  Mei-Lin Yang ,  Tsong-Long Hwang ,  Yuan-Yu Lai ,  Yue-Chiun Li ,  Tran Dinh Thang ,  Tian-Shung Wu
Affiliations
  • 1. Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, Republic of China.
PMID: 23347584 DOI: 10.1021/np300699f
Abstract

Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type Diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and Elastase release.