Antiviral phenolic compounds from Arundina gramnifolia

  • J Nat Prod. 2013 Feb 22;76(2):292-6. doi: 10.1021/np300727f.
Qiu-Fen Hu  1 ,  Bin Zhou ,  Jian-Ming Huang ,  Xue-Mei Gao ,  Li-Dan Shu ,  Guang-Yu Yang ,  Chun-Tao Che
Affiliations
  • 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming, Yunnan, People's Republic of China.
PMID: 23368966 DOI: 10.1021/np300727f
Abstract

Five new phenolic compounds, gramniphenols C-G (1-5), and eight known compounds (6-13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC(50) values of 20.8, 40.8, and 57.7 μM, respectively. Compounds 1-10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.