Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

  • Bioorg Med Chem Lett. 2013 Mar 15;23(6):1823-7. doi: 10.1016/j.bmcl.2013.01.032.
Nguyen Phuong Thao  1 ,  Le Duc Dat ,  Ninh Thi Ngoc ,  Vu Anh Tu ,  Tran Thi Hong Hanh ,  Phan Thi Thanh Huong ,  Nguyen Xuan Nhiem ,  Bui Huu Tai ,  Nguyen Xuan Cuong ,  Nguyen Hoai Nam ,  Pham Van Cuong ,  Seo Young Yang ,  Sohyun Kim ,  Doobyeong Chae ,  Young-Sang Koh ,  Phan Van Kiem ,  Chau Van Minh ,  Young Ho Kim
Affiliations
  • 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam; College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
PMID: 23395633 DOI: 10.1016/j.bmcl.2013.01.032
Abstract

Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8μM, respectively.